Host Missouri School for the Deaf fell behind 30-6 at halftime in dropping to 0-5 on the season after Wednesday night's 54-21 loss to Jamestown in a clash between Eagles.
Junior guard Ste'Quan Scott finished with 10 points and eight rebounds to guide MSD.
Trenton Barbour produced a game-high 12 points for Jamestown and Garrett Wolfe added 11.
MSD hosts Iowa School for the Deaf at 7:30 tonight, then plays Kansas School for the Deaf for homecoming at 7 p.m. Saturday.