JEFFERSON CITY - The Eagles were outscored by the Lions 21-6 in the first quarter of Tuesday night's loss.
MSD (9-10) trailed 31-16 at halftime and was down 35-24 after three quarters.
Senior center Mikal Meriwether topped the Eagles with a game-high 16 points, eight rebounds and three steals. Junior guard Conner Luper provided 10 points.
Cole Going and Kyle Hagemeyer led Calvary Lutheran with 11 points apiece.
MSD ends the regular season with a home contest against the Missouri Military Academy at 6 tonight.
The Eagles are seeded eighth in the Class 1, District 9 Tournament at St. Elizabeth. MSD meets No. 9 seed Tuscumbia in a play-in game at noon Saturday.