The Lady Owls were outscored 25-5 in the second quarter by the Lady Eagles in an American Midwest Conference loss in Thursday night's home opener at Anderson Arena.
William Woods University (1-1, 1-1 AMC) was on top 18-15 after one quarter, but Williams Baptist University (4-2, 1-0) used its second-quarter surge to establish a 40-23 edge over the Lady Owls at halftime.
The Lady Eagles then outscored William Woods 24-17 in the third quarter to extend their lead to 64-40.
Senior guard Tori Nesslage, freshman guard Natalie Thomas and junior guard Arriyonn Phillips finished with 13 points apiece to guide the Lady Owls, who shot a woeful 27% (18-of-67) from the field.
Nesslage collected a game-high 11 rebounds and Phillips followed with 10 as William Woods was edged on the boards 46-44. The Lady Owls were also outscored 32-20 in the paint and 46-13 by the Lady Eagles' reserves.
Reesa Hampton came off the bench to deliver a game-high 19 points as four players reached double figures for Williams Baptist. Tasia Bond added 13 points, Cassidy Clayton provided 12 and Sharisa Kimble contributed 10 as the Lady Eagles shot 45% (30-of-67) as a team.
William Woods remains at home for an AMC contest against Harris-Stowe State University at 1 p.m. Saturday.