As virus flares globally, new strategies target hotspots

FILE - In this Oct. 15, 2020, file photo, protesters gather on the sidewalk outside the offices of New York Gov. Andrew Cuomo in New York. After shutdowns swept entire nations during the first surge of the coronavirus earlier this year, some countries and U.S. states are trying more targeted measures as cases rise again around the world. In New York City's borough of Brooklyn, Orthodox Jews have complained their communities are being singled out for criticism. (AP Photo/Kathy Willens)
FILE - In this Oct. 15, 2020, file photo, protesters gather on the sidewalk outside the offices of New York Gov. Andrew Cuomo in New York. After shutdowns swept entire nations during the first surge of the coronavirus earlier this year, some countries and U.S. states are trying more targeted measures as cases rise again around the world. In New York City's borough of Brooklyn, Orthodox Jews have complained their communities are being singled out for criticism. (AP Photo/Kathy Willens)

NEW YORK (AP) - After entire nations were shut down during the first surge of the coronavirus earlier this year, some countries and U.S. states are trying more targeted measures as cases rise again around the world, especially in Europe and the Americas.

New York's new round of virus shutdowns zeroes in on individual neighborhoods, closing schools and businesses in hotspots measuring just a couple of square miles.

Spanish officials limited travel to and from some parts of Madrid before restrictions were widened throughout the capital and some suburbs.

Italian authorities have sometimes quarantined spots as small as a single building.

While countries including Israel and the Czech Republic have reinstated nationwide closures, other governments hope smaller-scale shutdowns can work this time, in conjunction with testing, contact tracing and other initiatives they've now built up.

The concept of containing hotspots isn't new, but it's being tested under new pressures as authorities try to avoid a dreaded resurgence of illness and deaths, this time with economies weakened from earlier lockdowns, populations chafing at the idea of renewed restrictions and some communities complaining of unequal treatment.

Confirmed world coronavirus infections surpassed 40 million, according to a Johns Hopkins University tally early Monday.

Some scientists say a localized approach, if well-tailored and explained to the public, can be a nimble response at a complex point in the pandemic.

"It is pragmatic in appreciation of 'restriction fatigue' but it is strategic, allowing for mobilization of substantial resources to where they are needed most," said Dr. Wafaa El-Sadr, who is following New York City's efforts closely and is on some city advisory boards.

Other scientists are warier.

"If we're serious about wiping out COVID in an area, we need coordinated responses across" as wide a swath as possible, said Benjamin Althouse, a research scientist with the Institute for Disease Modeling in Washington state.

In a study that has been posted online but not published in a journal or reviewed by independent experts, Althouse and other scientists found amid patchwork coronavirus-control measures in the U.S. this spring, some people traveled farther than usual for such activities as worship, suggesting they might have responded to closures by hopscotching to less-restricted areas.

Still, choosing between limited closures and widespread restrictions is "a very, very difficult decision," Althouse noted. "I'm glad I'm not the one making it."

Early in the outbreak, countries tried to quell hotspots from Wuhan, China - where a stringent lockdown was seen as key in squelching transmission in the world's most populous nation - to Italy, where a decision to seal off 10 towns in the northern region of Lombardy evolved within weeks into a nationwide lockdown.

After the virus's first surge, officials fought flare-ups with city-sized closures in recent months in places from Barcelona, Spain, to Melbourne, Australia.

In the English city of Leicester, nonessential shops were shut down and households banned from mixing in late June.

The infection rate fell, dropping from 135 cases per 100,000 to around 25 cases per 100,000 in about two months.

Proponents took that as evidence localized lockdowns work. Skeptics argued that summertime transmission rates were generally low anyway in the United Kingdom, where the official coronavirus death toll of over 43,000 stands as Europe's highest, according to figures compiled by Johns Hopkins University.

With infection levels and deaths rising anew in Britain, scientists have advised officials to implement a national, two-week lockdown. Instead, the government on Monday carved England into three tiers of coronavirus risk, with restrictions ranging accordingly.

"As a general principle, the targeting of measures to specific groups or geographical areas is preferable to one-size-fits-all measures, because they allow us to minimize the damage that social distancing inevitably imposes on society and the economy," said Flavio Toxvaerd, who specializes in economic epidemiology at the University of Cambridge.