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While there is not yet a vaccine approved to be used against COVID-19, Missouri leaders announced Thursday the state is ready for when that moment comes, with the state having submitted its vaccine distribution plan to the federal government.
Gov. Mike Parson said the state's plan was submitted Thursday afternoon to the Centers for Disease Control and Prevention.
State health director Dr. Randall Williams said the CDC will give feedback by Oct. 26 on the plan, but there won't be formal approval of the plan given by the agency.
Williams said there are four candidates for a vaccine in development — three of which require cold storage in temperatures such as 70 degrees below zero, and more than one dose.
He said the hope is that a vaccine will be available by late November or early December, with general availability for the public by April.
In the meantime, the limited amounts of vaccine that will be available initially will be reserved for critical and high-risk groups of people.
Williams said the state's vaccine distribution plan has three phases.
The first phase begins with people essential to other people's care — such as health care workers — the second phase expands to more groups of people, and then the third phase is general availability, "through drive-thru clinics, gyms, individual providers," he said.
On determining what groups of people should get the vaccine first, Williams said, "We've listened very carefully to the CDC. We've listened very carefully to national vaccine advisory groups. We've gone cross-departmentally."
He added the state is guided by wanting to get vaccine to people who are most at-risk of death and complications from comorbidities — which also includes people who work with vulnerable people, such as long-term care facility workers.
Comorbidities are underlying chronic health issues or conditions that put people at more risk for serious illness from the coronavirus that causes COVID-19.
According to the state's plan released Thursday, the first phase of distribution would itself be broken into two parts. The first half, 1A, would focus on vaccinating "unpaid and paid healthcare workers."
"Missouri plans to collaborate with healthcare systems, pharmacies, and community partners to vaccinate long-term care facility staff and other healthcare workers. If the need arises to break this group further down, Missouri plans to start with healthcare staff at long-term care facilities," according to the plan.
"The next step is healthcare workers who self-identify recognized CDC established comorbidities for COVID-19, starting with inpatient healthcare workers (and) expanding out to outpatient healthcare workers."
In the second half of the first phase of distribution, 1B, vaccination would be expanded to include "critical infrastructure workers and Missourians at higher risk for COVID-19 disease identified by the CDC established comorbidities for COVID-19."
People who are older than 65 are specifically mentioned as having an increased risk, but other people at increased risk for severe illness from COVID-19 would also be prioritized in phase 1B. The plan notes that research to date has shown obesity, kidney disease, asthma, lung disease, diabetes, high blood pressure and heart disease are all comorbidities associated with increased risk for severe illness from COVID-19.
The state would work with "local health care providers, community organizations, their partners and local public health agencies" to perform phase 1B vaccinations where possible.
Critical infrastructure workers also prioritized in phase 1B would include non-hospital EMS, police officers, firefighters, prison workers, childcare workers, teachers and other school staff, select state emergency management workers, water purification and wastewater treatment workers, people who support the functioning of the electrical grid, workers of factories identified as critical infrastructure, workers at "mass facilities for the production or processing of food," and "employees identified by their employers as 'essential employees' (typically applied during weather emergencies)."
The second phase of vaccine distribution would be intended to "Secure the critical infrastructure of Missouri and accelerate economic recovery within the state," according to the plan.
That includes vaccinating anyone among priority groups missed in the first phase, as well as vaccinating "populations at increased risk of acquiring or transmitting COVID-19. These populations of consideration include racial and ethnic minority groups, housing-insecure individuals, people living and working in congregate settings, and other groups and other communities at higher risk of severe outcomes from COVID-19."
Additionally, "The staff of manufacturing facilities identified as critical infrastructure or critical to national security is, by definition, essential to the economy and safety of the State as part of Phase 2."
In total, the state's vaccine distribution plan estimates there are approximately 425,000 healthcare workers who would be among the populations prioritized in the first two phases of vaccine distribution — along with approximately 31,000 first responders; more than a million adults over the age of 65; almost 1.3 million adults with high-risk underlying conditions; more than 16,000 childcare workers; more than 250,000 teachers and school staff; 1,300 water and wastewater workers; more than 2,200 energy workers; 150,000 manufacturing employees; and 50,000 food and agriculture plant workers.
That would be approximately 3.3 million people in priority groups — more than half the population of Missouri — and 6.6 million doses of vaccine, if two doses are ultimately required.
During the second phase of distribution, the state would also prepare for vaccination of the general public, "depending on vaccine quantities," and authorities would "continue providing a regional approach" to vaccinating the rest of Missouri's population.
At phase three, the state would "focus on making sure every Missourian who qualifies and needs or wants a COVID-19 vaccine receives the requested vaccine at no cost," according to the plan.
Furthermore, "The intention is federally qualified health centers, rural health clinics, private providers and pharmacies take on the majority of the vaccination effort for most adults in their areas. Local public health authorities and the state health authority will target vaccination efforts toward the most vulnerable populations, such as homeless populations with limited access to care and local incarcerated individuals, and assist with college and university vaccination efforts."
To assist in those efforts, the state would use a mobile medical unit, "as needed or requested," staffed with a Department of Health and Senior Services team who would be dedicated to that mobile vaccination unit.
"The mobile unit will devote days and times in various locations to provide the COVID-19 vaccine to at-risk populations. State health authorities will work with local health authorities and community organizations to identify vaccination sites and communicate available vaccination days to the population.
"Community partners will need to identify other resources for vaccinating hard-to-reach populations. This will also help local and state health authorities to provide vaccinations to outbreaks in these communities."
The state would also support private providers, federally-qualified health centers, rural health clinics and pharmacies by making available vaccination supplies, vaccines and appropriate personal protective equipment, "so cost is not a barrier to patient vaccination."
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Also during the third phase, the state "will work toward routine annual vaccination for the qualifying population."
On encouraging the public's trust of a vaccine, Williams said, "To even get to the FDA, it has to go through very reputable companies, whose scientists have spent their whole lives staking their reputations" on development of safe vaccines.
Once before the Food and Drug Administration, that agency involves outside stakeholders through national academies in its approval process, Williams said.
Once approved by the FDA, he said a vaccine faces scrutiny by a national advisory committee, and then the CDC — altogether, an "incredibly-layered approach" involving private and public entities.
Parson added he would not issue a mandate for people to be vaccinated.