Junior guard Joseph Allen led the Eagles with 14 points as they bowed to the Lions at home 58-41 in their regular-season finale on Wednesday.
Sophomore guard Ste'Quan Scott added 10 points, while senior forward Benson Goodwin added seven points and nine rebounds for MSD (8-10).
After falling behind 14-5 in the first quarter, the Eagles crawled back to within 28-17 at halftime. Calvary Lutheran outscored MSD 30-24 in the second half.
Beau Monson scored a game-high 16 points for the Lions. Luke Allen pitched in with 10 points.
The Eagles - the No. 7 seed in the Class 1, District 9 tournament - take on No. 2 seed Tuscumbia in a first-round pairing at 8:30 p.m. next Tuesday in Jamestown.