McKenzie Ausfahl logged a team-high 17 points to push the Ladybirds to a season-opening 33-21 win on Monday night.
Alesa Lee also finished in double digits with 10 points.
Logan Blevins and Natalie Thomas each produced 10 points in leading North Callaway's seventh-grade team to a 31-17 win over Wellsville.
The Ladybird eighth-graders play at Community R-VI at 6 p.m. Thursday. The seventh-grade team will play at Hallsville at 10 a.m. on Saturday.